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Senior Research Technologist, Developmental Neurobiology
Eingestellt von Bio Careers
Projektbeschreibung
We have recently developed a novel system to reprogram mature differentiated retinal neurons into iPSCs using the 4 Yamanaka factors or into ESCs using somatic cell nuclear transfer. We have developed over 500 lines from each of the major classes of cell types in the murine retina and characterization is ongoing. Of particular importance, we have successfully made retina in 3D culture from the iPSC and ESC lines and shown that some retain epigenetic memory of their retinal origins. We are now planning to extend our findings to human retinal neurons. We are seeking a senior research technologist with experience in murine or human iPSC or ESC culture and differentiation. The Senior Research Technologist will lead efforts to produce new human iPSCs and optimize retinal differentiation in vitro for human cells. The Senior Research Technologist will have the opportunity to gain experience with epigenetic profiling of the human and murine ESC lines as well as generating novel murine strains to begin to explore the underlying mechanism of the epigenetic memory. This research will advance our understanding of normal retinal development, retinoblastoma initiation and progression and it may directly impact efforts to develop cell-based therapies to treat retinal degeneration.
Projektdetails
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Einsatzort:
Memphis, Vereinigte Staaten
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Projektbeginn:
asap
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Projektdauer:
Keine Angabe
- Vertragsart:
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Berufserfahrung:
Keine Angabe
Geforderte Qualifikationen
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Kategorie:
Sonstiges