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Senior Research Technologist, Developmental Neurobiology

Eingestellt von Bio Careers

Projektbeschreibung

St. Jude Children's Research Hospital, founded by the late entertainer Danny Thomas, is one of the world's premier centers for the research and treatment of pediatric cancer and other catastrophic childhood diseases. St. Jude is the first and only pediatric cancer center to be designated as a Comprehensive Cancer Center by the National Cancer Institute. Children from all 50 states and from around the world have come through the doors of St. Jude for treatment, and thousands more around the world have benefited from the research conducted at St. Jude - research that is shared freely with the global medical community. St. Jude is the only pediatric cancer research center where families never pay for treatments that are not covered by insurance. No child is denied treatment because of a family's inability to pay.

We have recently developed a novel system to reprogram mature differentiated retinal neurons into iPSCs using the 4 Yamanaka factors or into ESCs using somatic cell nuclear transfer. We have developed over 500 lines from each of the major classes of cell types in the murine retina and characterization is ongoing. Of particular importance, we have successfully made retina in 3D culture from the iPSC and ESC lines and shown that some retain epigenetic memory of their retinal origins. We are now planning to extend our findings to human retinal neurons. We are seeking a senior research technologist with experience in murine or human iPSC or ESC culture and differentiation. The Senior Research Technologist will lead efforts to produce new human iPSCs and optimize retinal differentiation in vitro for human cells. The Senior Research Technologist will have the opportunity to gain experience with epigenetic profiling of the human and murine ESC lines as well as generating novel murine strains to begin to explore the underlying mechanism of the epigenetic memory. This research will advance our understanding of normal retinal development, retinoblastoma initiation and progression and it may directly impact efforts to develop cell-based therapies to treat retinal degeneration.

Projektdetails

  • Vertragsart:

    Contract

  • Berufserfahrung:

    Keine Angabe

Geforderte Qualifikationen

  • Kategorie:

    Sonstiges

Bio Careers