Quantitative Biomarker LC-MS/MS Scientist

JOB FOCUS:

- A position is available for a skilled bioanalytical scientist to join a state-of-the-art mass spectrometry laboratory in PDM with deep expertise in bioanalytical quantitation.
- The lab based role entails the development of ultra-sensitive quantitative assays for small and large molecule biomarkers in relevant cells and biological fluids (plasma, tissue, etc.).
- This position requires strong bioanalytical expertise, proven expertise in chromatography, triple quadrupole quantitative mass spectrometry and potentially HRMS.
- Experience with super critical fluid chromatography, immunoaffinity enrichment techniques or nano scale chromatography is a plus.
- The candidate will participate in all phases of mass spec laboratory operations including the development of sample preparation and separation methods, assay execution, instrument maintenance, data analysis and reporting.

RESPONSIBILITIES:

- Run bioanalytical assays under minimal supervision; initiative in method development is expected.
- Independent daily operation, calibration, maintenance, and troubleshooting of multi-dimensional chromatography and triple quadruple mass spectrometry instrumentation (high flow to nano scale, HPLC and SFC).
- Support analysis of lipid panel using SFC-MS/MS
- Support analysis of quantitative LC-MS/MS data using relevant bioinformatics and quantitation software.
- Apply existing protein quantitation workflows using bead and column based immunoaffinity enrichment including the use of automation.
- Support biomarker and PK/PD studies as needed. Experience with Watson is a plus.

QUALIFICATIONS, TECHNICAL SKILLS AND EXPERIENCE:

- BS/MS level education in chemistry, biochemistry or related fields required; advanced degree may be a plus.
- Industry experience in biopharma preferred.
- Expertise in the operation and maintenance of LCs and mass spectrometers.
- Experience with basic and complex quantitative LC-MS/MS assays (both large and small molecule LCMS).
- Track record of method development skills particularly with novel and complex methods applied to bioanalytical questions.
- Work well both independently and as part of a team. Collaborative skills and effective partnering skills in a Matrix environment.
- Strong data organization and analysis skills and passion to learn new things in a fast paced environment.
- Strong communication skills.
- High Performance Liquid Chromatography (HPLC)
- Strong Excel based skills is also a plus.