Postdoctoral Fellowship in Cell Biology

One NIH-funded Postdoctoral position is available in the Mahjoub lab to study the regulation of centrosome and cilium assembly and function. These highly conserved organelles act as signaling hubs that regulate diverse aspects of cell-cycle progression, cell differentiation, polarity, and migration. Defects in the structure and function of centrosomes and cilia lead to a wide range of human disease phenotypes including polycystic kidney disease, nephronophthisis, polydactyly, infertility, hydrocephalus and cancer.

We employ cutting-edge genomic, proteomic, biochemical and cell biological methods to delineate the regulation of centrosome-cilium assembly and function. Current experiments are focused on:

(1) determining the molecular mechanisms of protein trafficking and localization to cilia.

(2) proteomic and biochemical approaches to identify regulatory proteins involved in centriole assembly, duplication and ciliogenesis.

(3) examining the consequences of abnormal centrosome and cilium function in human disease, with particular emphasis on cystic kidney disease and cancer.

For a more detailed description of our research visit mahjoublab.dom.wustl.edu .