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Post-Doctoral Fellow
Eingestellt von Bio Careers
Gesuchte Skills: Support
Projektbeschreibung
Specific Position Duties with Percentages of Time
The Theodorescu Lab at the University of Colorado Anschutz Medical Campus is seeking a highly motivated individual to investigate the role of chromatin remodeling and transcriptional co-activator proteins in bladder tumorigenesis and metastasis. Exome sequencing of tumors from >100 bladder cancer patients was performed in the lab to define the mutational landscape of bladder cancer. It was discovered that CBP and its paralog p300 are 2 of the 4 most frequently mutated genes in bladder cancer (Nature Genetics, 43, 875-878, 2011). Hence, studying the impact of CBP and p300 mutations on histone acetylation, transcriptional activation, tumor growth, and patient prognosis in bladder cancer will provide novel insights into CBP/p300 function and clinically useful biomarkers and therapeutics in bladder and possibly other cancers. The successful candidate will work in a highly collaborative lab environment and have access to an extensive number of core facilities and bioinformatic support.
Projektdetails
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Einsatzort:
Denver, Vereinigte Staaten
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Projektbeginn:
asap
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Projektdauer:
Keine Angabe
- Vertragsart:
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Berufserfahrung:
Keine Angabe
Geforderte Qualifikationen
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Kategorie:
Sonstiges