Computational Modeling Scientist

Computational Modeling Scientist
Memphis, TN

St. Jude Children's Research Hospital, located in Memphis, Tennessee, is a premier center for research and treatment of potentially fatal childhood diseases, including cancer and certain blood, genetic, and immunodeficiency disorders. The hospital's mission is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. St. Jude is dedicated to providing unsurpassed patient care and to advancing the health of children through biomedical research.

ST. JUDE CHILDREN\'S RESEARCH HOSPITAL has an opening for a COMPUTATIONAL MODELING SCIENTIST (JOB NUMBER 30906).

The COMPUTATIONAL MODELING SCIENTIST designs and develops experiments for quantitative characterization of solid tumor dynamics and cancer biology for multi-scale computational modeling of solid tumor growth and evolution. Coordinates a complex set of experiments, including designing pre-clinical trials and processes and analyzing the collected data. Designs, implements and validates predictive multi-scale computational models of solid tumors. RESPONSIBILITIES: 1. Designs, performs and supervises in vivo and ex vivo tumor microscopy experiments. a. Coordinates between the various institutional core facilities involved. b. Coordinates with the light microscopy core facility in particular. c. Participates in the design and implementation of equipment 2. Designs and develops image processing and analysis of multi-dimensional experimental data. a. Works with digital whole slide scanners (Aperio/Leica). b. Develops tissue classifiers using genetic algorithms. c. Processes experimental imaging data into quantitative parameters. 3. Analyzes genomic data (Affymetrix, etc) for integration into the computational model. 4. Develops multi-scale predictive computational models of solid tumor growth and cancer evolution using multi-scale experimental data. a. Integrates various data types into a single computational framework. b. Designs and optimizes CompuCell3D code accordingly. c. Works with software engineer to efficiently run code on institutional clusters. 5. Uses computational models to suggest new experiments and generate hypotheses of heterogeneity in solid tumor growth and evolution. 6. Assists in preparation of grant proposals, journal publications, and presentations for professional meetings. 7. Trains and supervises computer scientists, research assistants and graduate students participating in the project. 8. Performs other duties as assigned to meet the goals and objectives of the department and institution.