Cell and Gene Therapy Technical Development Technician

SUMMARY:

- We are seeking a highly motivated, results oriented, self-starter who demonstrates personal accountability for outcomes and thrives on increasing levels of responsibility, to help with the start-up of a new Cell Engineering Facility and participate in the development and characterization of manufacturing processes
- Application of bioprocessing approaches such as DOE, media development, disposable processing technologies and automation to the engineering, expansion and cryopreservation of Chimeric Antigen Receptor T-cell (CART) therapies.

JOB RESPONSIBILITIES:

- Help with operational start-up of a new CART process development lab space
- Participate in information/tech transfer from external collaborator and implementation of CART processing technologies (T-cell isolation, activation, genome-engineering, expansion, cryopreservation, and supporting/associated analytical characterization methods)
- Contribute to relevant and impactful innovation programs to enhance CART manufacturing technologies/capabilities and work processes (such as alternate transfection/cell engineering strategies, media development, disposable/closed production systems and automation) as needed/appropriate.
- Work closely with Project Team and key partners - communicate and collaborate effectively to ensure seamless interfaces and interactions with all stakeholder groups
- Apply scientific and technical experience to establish safe, high-quality lab practices, and demonstrate strong personal leadership and technical and interpersonal skills
- Ensure high-quality, timely documentation in electronic laboratory notebooks and contribute to and Technical Reports as appropriate.

SKILLS:

TECHNICAL SKILLS REQUIREMENTS:

- Degree in Molecular Immunology/Molecular Biology or related field or Chemical Engineering degree (with appropriate Cell and Gene Therapy focus) with relevant laboratory experience (BSc +5 years/MSc +3 years), preferably in biotech/biopharma industry.
- Process development for manufacturing of cell or gene-therapies
- T cell molecular biology/engineering and characterization of primary T cells
- Molecular virology/engineering and production of recombinant viruses
- Mammalian cell genome engineering
- Development of analytical methods for characterization of cell-based or gene-therapies - experience with cell-based and flow-cytometry-based assays for characterization of cell populations and/or activity
- Cell/Tissue Culture