Cell and Gene Therapy Technical Development Technician

SUMMARY:

- We are seeking a highly motivated, results oriented, self-starter who demonstrates personal accountability for outcomes and thrives on increasing levels of responsibility, to help with the start-up of a new Cell Engineering Facility
- Participate in the development and characterization of manufacturing processes - application of bioprocessing approaches such as DOE, media development, disposable processing technologies and automation to the engineering, expansion and cryopreservation of Chimeric Antigen Receptor T-cell (CART) therapies.

JOB RESPONSIBILITIES:

- Help with operational start-up of a new CART process development lab space
- Participate in information/tech transfer from external collaborator and implementation of CART processing technologies (T-cell isolation, activation, genome-engineering, expansion, cryopreservation, and associated characterization)
- Contribute to relevant innovation programs to enhance CART manufacturing technologies/capabilities and work processes (such as alternate transfection/cell engineering strategies, media development, disposable/closed production systems and automation) as needed/appropriate.
- Work closely with Project Team and key partners - communicate and collaborate effectively to ensure seamless interfaces and interactions with all stakeholder groups
- Apply scientific and technical experience to establish safe, high-quality lab practices, and demonstrate strong personal leadership and technical and interpersonal skills
- Ensure high-quality, timely documentation in electronic laboratory notebooks and contribute to and Technical Reports as appropriate.

SKILLS:

TECHNICAL SKILLS REQUIREMENTS:

- Degree in Molecular Immunology/Molecular Biology or related field or Chemistry Engineering degree (with appropriate Cell and Gene Therapy focus) with relevant laboratory experience
- (BSc +5 years/MSc +3 years), preferably in biotech/biopharma industry.
- Process development for GMP biomanufacturing (DOE, media development, disposable processing technologies automation - prior experience with cell- or gene therapy process development preferred)
- Relevant cell and molecular biology experience such as production/characterization of recombinant viruses or growth and molecular engineering of primary T cells
- Familiarity with cGMPs and relevant Regulatory Guidance documents
- Cell/Tissue Culture