Bench Scientist

ROLE DESCRIPTION

- Cellular therapeutics, such as chimeric antigen receptor (CAR) based T-cells, are demonstrating tremendous promise in oncology.
- This position will be part of this nascent group to help propel company into this avenue of exciting research and address unmet medical needs.

RESPONSIBILITIES

- This scientist will be involved in establishing methodologies, ie culturing and activating primary T-cells, enriching T-cell populations, viral transductions and electroporation of primary cells, to generate CAR T-cells.
- They will also be responsible for CAR T-cells based on current state of the art and novel constructs in vitro and in vivo to identify optimal constructs and characteristics for therapeutic uses.

SKILLS

EDUCATION AND EXPERIENCE 

- BS and 5+ years of experience or MS and 3+ years of experience in an academic and/or industrial setting.
- Knowledge and hands-on experience in generating and optimizing human CAR T-cells is required.
- Knowledge and experience of modern laboratory methodology in cellular and molecular T-cell immunology.
- Knowledge and experience with viral based systems (lentivirus, adenovirus, or murine retrovirus) to optimize transduction of cell-lines and primary cells.
- Knowledge and experience in genome engineering (zinc fingers, TALEN, or CRISPR) is preferred.
- Excellent written, oral communication skills.
- Biochemical Techniques
- Cell/Tissue Culture