Post-Doctoral Fellowship in Understanding Alzheimer's Disease Pathogen

The National Institute on Aging (NIA), a major research component of the National Institutes of Health (NIH) and the Department of Health and Human Services (HHS), is recruiting postdoctoral fellows with interests in Alzheimer's disease (AD) and/or age-associated memory impairment (AAMI) in the Unit of Clinical and Translational Neuroscience, within the Laboratory of Behavioral Neuroscience.
This research represents an exciting new initiative within the NIA intramural research program (IRP) to enhance our understanding of disease mechanisms underlying risk factors for AD/AAMI, discover biologically relevant biomarkers that accurately reflect neuropathology and identify potential targets for effective disease modification/intervention. These studies combine multimodal neuroimaging methods to delineate changes in brain structure/function associated with both genetic and environmental risk factors for AD/AAMI (for eg: Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype. Biol Psych. 2013, 73(5):422-428; Alzheimer risk variant CLU and brain function during aging. Biol Psych. 2013, 73(5):399-405; Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging. Nerobiol Aging. 2013, 34(10):2271-6; Glucose intolerance, insulin resistance and Alzheimer's disease pathology in the Baltimore Longitudinal Study of Aging. JAMA Nerol. 2013, 70(9): 1167-72).

The research benefits from the unique and rich longitudinal dataset available in the Baltimore Longitudinal Study of Aging (BLSA) as well as complementary patient cohorts such as AddNeuroMed that are available as part of ongoing international collaborations (for eg: Plasma biomarkers of brain atrophy in Alzheimer's disease. PLoS One. 2011;6(12):e28527).

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